He was eminent alike for knowledge of rabbinical matters and for scholarship in the science of his day, particularly natural physics and astronomy, furnishing commentaries upon many treatises translated from the Arabic and Latin.
In 1570, Almosnino wrote a lengthy Hebrew commentary on the Biblical "Five scrolls"—the books of Canticles, Ruth, Lamentations, Ecclesiastes, and Esther—under the title Yede Mosheh ("The Hands of Moses"); also an exposition of the Talmudical treatise Abot "Ethics of the Fathers" called Pirkei Moshe, published at Salonica in 1563; and a collection of sermons delivered upon various occasions, particularly funeral orations, entitled Meammeẓ.
To this was appended a chapter on "Dreams, Their Origin and True Nature," written, as it is stated, at the request of Don Joseph Nasi, Duke of Naxos.
An edition in Spanish letters was published by Samuel Mendes de Sola and associates in Amsterdam, 1729, dedicated to Aaron David Pinto.
A historical work by Almosnino, Extremos y Grandezas de Constantinopla, also in Spanish with Hebrew characters, was transliterated and republished by Jacob Cansino, Madrid, 1638.