After his graduation from University of Engineering and Technology, Lahore in 1966 he joined politics and was elected as a Member of the Provincial Assembly (MPA) of what was then East Pakistan in 1970.

1), the highest policy-making post of the Awami League, the oldest and traditional political organization of the country.

Mosharraf Hossain began his political career as a member of the East Pakistan Provincial Council in 1970.

[6] The Anti-Corruption Commission filed charges against Hossain in May 2007 over irregularities in the allocation of commercial land in Chittagong.

[9] After serving seven terms as a member of parliament from Chittagong-1 (Mirsarai), Mosharraf Hossain handed his nomination to his son, Mahboob Rahman (Ruhel), who was elected in the 12th national polls on 7 January 2024.