The area was originally populated by Balto-Finnic peoples; Krivich Slavs arrived later.

By the 16th century, the area belonged to Bezhetskaya pyatina of the Grand Duchy of Moscow.

In 1796, the viceroyalty was abolished, and the area, which was a part of Borovichsky Uyezd, was transferred to Novgorod Governorate.

Much of the current territory of the district was a part of Nikolo-Moshenskaya Volost of Borovichsky Uyezd.

[12] On July 23, 1930, the okrugs were abolished, and the districts were directly subordinated to the oblast.

[14] On July 5, 1944, Moshenskoy District was transferred to newly established Novgorod Oblast,[12] where it remained ever since with a brief interruption between 1963 and 1965.

[16] In 1927, Orekhovsky District with the administrative center in the selo of Klimkovo[17] and Konchansky District with the administrative center in the selo of Konchanskoye[18] were also established, both as a part of Borovichi Okrug of Leningrad Oblast.

The main agricultural specializations in the district were cattle breeding (with meat and milk production) and growing of potato and crops.

[3] A paved road connecting Pestovo and Borovichi crosses the district from east to west.

The Uver River was used as a part of Vyshnevolotsky Canal System constructed in the 18th century to bypass the rapids on the Msta.

Alexey Maksheyev, an author and historian, as well as a military officer, was born in Olekhovo,[clarification needed] which was his family estate and is currently located within the limits of the district.