Mosopelea

The Mosopelea or Ofo (also Ofogoula) were a Siouan-speaking Native American people who historically lived near the upper Ohio River.

In reaction to Iroquois Confederacy invasions to take control of hunting grounds in the late 17th century, they moved south to the lower Mississippi River.

Shortened in the Shawnee language, the name evolved to "Pelisipi" or "Pellissippi" and was also later applied to what is now called the Clinch River in Virginia and Tennessee.

La Salle recorded that the Mosopelea were among the tribes conquered by the Seneca and other nations of the Iroquois Confederacy in the early 1670s, during the later Beaver Wars.

[5] In 1673, Marquette, Joliet, and other early French explorers found that the Mosopelea likely abandoned Ohio and moved south along the Mississippi River.