Indian removals in Ohio started in the late eighteenth century after the American victory in the Revolutionary War and the consequent opening of the Northwestern United States to European-American settlement.
The process of obtaining full American sovereignty over Indian territories in Ohio was complete around 1818, but continued in Indiana until 1840.
[1] The Royal Proclamation of 1763 reserved what was then Ohio Country and lands beyond west of the Appalachians for Indians, and settlement by European colonists was forbidden.
Major United States army campaigns to assert sovereignty over the frontier ensued, culminating in the decisive American victory at Battle of Fallen Timbers in 1794.
[1] The United States dictated terms of the peace following the War, circumscribing a boundary line around state territories of Connecticut Western Reserve and Virginia Military District, along with the Symmes and Ohio Company land purchases to include most of southern and eastern Ohio in an area reserved to settlers.