[1] The Knights of Peter Claver, the largest and oldest Black Catholic organization in the United States, was founded by congregants and priests from the parish in 1909.

The school was first taught by the laity, until five Sisters of St. Francis arrived from Glen Riddle, Pennsylvania in October 1902 to take over.

[5] During the civil and political rights era in the United States, priests and nuns from the parish participated in boycotts and demonstrations in support of the African American community.

[4][5] Neighborhood Organized Workers (NOW) was established in Mobile in July 1966 with a mission focused on achieving equality for the African American community.

[6] The church is listed on the African American Heritage Trail of Mobile.