After putting her deeper creative ambitions on hold to raise her two children, Eliza lives and works in a walk-up tenement in the middle of Greenwich Village.
Her good-natured but absent-minded husband (Anthony Edwards) seems tuned out to his wife's conflicts, not to mention basic domestic reality, while her best friend Sheila (Minnie Driver) understands this - and Eliza - too well.
With her daunting to-do list kicking off at dawn, Eliza has to prepare for her daughters 6th birthday party, mind her toddler son, battle for parking space during an epic alternate side parking showdown, navigate playground politics with overbearing mums, and mend a rift after posting her best friends intimate confession on her blog.
MOTHERHOOD is a bitter sweet comedy and the mother of all movies about parenting - a hymn to the joys and sorrows of raising children, and the necessity of losing yourself in the process.
The website's critics consensus reads: "Despite Uma Thurman's comic skills, Motherhood's contrived set-ups and clichéd jokes keep this comedy from delivering laughs – or insights into modern parenting.
There are some smiles and chuckles and a couple of actual laughs, but the overall effect is underwhelming"; Thurman is "doing her best with a role that may offer her less than any other in her career, even though she's constantly onscreen.