Motsamai Keyecwe Mpho (February 3, 1921 – November 28, 2012) was a Motswana activist and politician.

He founded Botswana's first political party in 1960, the Botswana People's Party, then known as the Bechualand People's Party, alongside Klaas Motshidisi, Kgalemang Motsete, and Philip Matante.

[1] Some historians believe that Mpho was the first to introduce the term 'Botswana' into formal political vocabulary, replacing the colonialist name of Bechuanaland.

[2] He married his wife, Onalepelo Hannah Macheng, on 7 July 1960, whilst incarcerated in Pretoria Prison for treason in South Africa.

[4] Mpho died at Princes Marina Hospital in Botswana on November 28, 2012.