[1][2] Its main campus is located at 330 Mount Auburn St, in the neighborhood of West Cambridge.

[10][11][9] 2002 saw Mount Auburn's provision to introduce a more automated physician order entry (POE) system throughout the hospital, starting with the labor and delivery ward.

[12] In November 2008, the hospital opened the $80 million six-floor, 274,000 square feet (25,500 m2) Frank Stanton Building expansion project at its main 330 Mount Auburn Campus.

[13][14][15][16] In 2012 Mount Auburn Hospital's cardiac surgery received a top 100 rating from HealthGrades.

[18] In late 2014, Mount Auburn signed a $110 million contract with Epic Systems to implement a new electronic health record platform, called MyChart, for patients.