Located on a 77-acre (31 ha) campus just outside of the suburb of Reynoldsburg, the hospital serves the east side of Columbus as well as other smaller communities.

It is located off Interstate 270[2] and is accessible from the Central Ohio Transit Authority (COTA) public transport network.

In 2003, a new four-story tower opened, dedicated to expanding both the heart diagnostic, surgical and treatment capacity along with a new maternity unit.

A new five-story patient tower and several additions to the hospital had the specific focus of expanding the capacity services offered on-site.

In 2000, Mount Carmel joined Trinity Health, the third largest Catholic healthcare system in the United States.

[12] In 2003, Mount Carmel East opened a new four-story, $66 million tower[9] with a focus on cardiac and maternity care.

The facility was named after Bruce E. Siegel MD, one of the first members of the medical staff at Mount Carmel East.

[22] In 2016, Mount Carmel East received a "B" Hospital Safety ScoreSM from the Leapfrog Group, an independent nonprofit run by employers and other large purchasers of health benefits, whose stated goal is to save "lives by reducing errors, injuries, accidents and infections.”[23] In the fall of 2017 the Leapfrog Group again rated Mount Carmel East a "B".

For the use of staff, patients, and visitors the hospital has several dining establishments including Subway as well as the Mount Carmel East Cafeteria open seven days a week.

[25] Mount Carmel Health System uses onsite security officers equipped with collapsible batons and pepper spray but who do not carry firearms.

Many of the hospital's service areas were earmarked for this expansion, the most notable being a new 284,000-square-foot (26,400 m2) six-story tower with one story below ground,[27] the conversion of the existing 419 beds to 381 all-private patient rooms as well as a thorough reconstruction of the original structure.

[32] The hospital is accessible by public transport via COTA bus services operating throughout metropolitan Columbus, Ohio.

They are also located close to John Glenn Columbus International Airport allowing fixed wing air ambulance aircraft to land nearby.

[33] Surgeons at Mount Carmel East helped develop the SpineMask technique for a new type of spinal surgery.