Current programs include removal and control of feral animals, rehabilitation of degraded areas, and wildfire management.

[3] Floristically, Mount Gibson contains elements of both the south-west region and the arid zone, due to its transitional location on the mulga-eucalypt line.

[3] Both red and western grey kangaroos are found on the reserve, emphasizing the transitional nature of its location.

Significant bird species include malleefowl, Major Mitchell's cockatoo and regent parrot.

[6] The sanctuary, along with the neighbouring Charles Darwin Reserve, forms part of the 2,335-square-kilometre (902 sq mi) Mount Gibson and Charles Darwin Important Bird Area (IBA), so identified by BirdLife International principally because it supports populations of malleefowl and western corellas, as well as several other species restricted to either the arid or mallee biomes.