Mount Holmes is a prominent mountain peak in Yellowstone National Park.

Mount Holmes is located in the northwestern part of the park and marks the southern terminus of the Gallatin Range.

There was a historic fire watch tower near the top of Mount Holmes, before it was burned due to a lightning strike.

In 1878 Henry Gannett and geologist William H. Holmes, members of the third Hayden Geologic Survey, ascended the peak.

The trailhead is located near Apollonaris Spring on the Mammoth-Norris section of the Grand Loop Road.