The hospital is located adjacent to the Pennsylvania State University main campus near Beaver Stadium.

Some of the notable expansions include the addition of a new 52,000 square foot state-of-the-art east wing in 2010 and a comprehensive Cancer Center in 2012.

[7][8] Mount Nittany Medical Center was the only hospital with an emergency department in Centre County until Penn Highlands State College opened in 2024.

[12] Mount Nittany is a founding member of the Penn State Hershey Cancer Institute (PSHCI).

[4] The organization operates several locations with its Mount Nittany Physician Group, including a four-story outpatient center that opened in 2024.