Mountain Lake Run is a tributary of Stafford Meadow Brook in Lackawanna County, Pennsylvania, in the United States.

[2] There are stone walls from the time of the Works Progress Administration at one point in the watershed of Mountain Lake Run.

It also flows through a culvert system for a substantial part of its length in its lower reaches, beginning below Wintermantle Avenue.

[2] Mountain Lake Run is entirely within the United States Geological Survey quadrangle of Scranton.

Most of the watershed contains native mixed hardwood trees, but there is some impact from coal mining in its upper reaches.

However, neighborhoods in the watershed include Mountain Lake Estates, Robinson Park, and Bolus subdivision.

Around 1938, the Works Progress Administration created stone walls and culverts on the stream near the Mattes Community Center.