His father, then a customs officer, gave him $200 and a copy of the Quran before he left for the United States to study film direction and production at the University of California, Los Angeles (UCLA).
Akkad spent a further three years studying for a Master's degree at the University of Southern California (USC), where he met the director Sam Peckinpah.
Peckinpah became Akkad's mentor in Hollywood and hired him as a consultant for a film about the Algerian War that never made it to the big screen, but he continued to encourage him until he found a job as a producer at CBS.
In 1976, he produced and directed Mohammad, Messenger of God (released as The Message in 1977 in the United States), starring Anthony Quinn and Irene Papas.
In 1980 he directed Lion of the Desert, in which Quinn and Irene Papas were joined by Oliver Reed, Rod Steiger, and John Gielgud.
It was about the real-life Bedouin leader Omar Mukhtar (Quinn), who fought Benito Mussolini's Italian troops in the deserts of Libya.
Clint Morris describes the movie as: "A grand epic adventure that'll stand as a highpoint in the producing career of Moustapha Akkad.
At the time of his death, he was in the process of producing an $80 million movie featuring Sean Connery about Saladin and the Crusades, for which he already had the script, that would be filmed in Jordan.