Mouzaki (Greek: Μουζάκι, romanized: Mouzáki) is a town and a municipality in the northwestern part of the Karditsa regional unit, Greece.

Mouzaki is located on the southwestern edge of the Thessalian plain, where the river Pamisos descends from the Agrafa mountains.

The Greek National Road 30 (Arta - Trikala - Karditsa - Volos) passes north of the town.

[3] The municipal unit of Mouzaki is divided into the following communities (constituent settlements in brackets):[2] Not far from the town is one of the most popular climbing sites and venuvenues in Greece, the Mouzaki crag.

the crag creates a natural balcony overlooking the Pamisos river.