[1] The series starred Karl Swenson as a New York police detective who is a master of disguise, and who assumes a new identity in each episode in order to catch a criminal.
[1] In addition to Swenson, Frank Butler was heard in the role of Dave Arnold[6] (a sergeant who was Mr. Chameleon's assistant[7]), and Richard Keith portrayed the police commissioner.
[8] A review of the premiere episode in the trade publication Variety said that the cast "turns in graphic characterizations" and rated the quality of production as "Grade A throughout".
[9] A review in the trade publication Billboard during the fourth year of Mr. Chameleon described it as "actually nothing but a night time soap opera in the camouflage of a weekly mystery series.
"[10] It said that in the specific episode being reviewed, "Script, performance and production were all ridiculously melodramatic and devoid of any real character or animation.