"Mr. E's Beautiful Blues" is a song by the American rock band Eels, released February 14, 2000 in the UK, and is the first single to be released from their third album, Daisies of the Galaxy (2000).

[1] It was produced and co-written by Michael Simpson of the Dust Brothers.

Mark Oliver Everett wrote the song after finishing writing the album, and the record company insisted he put it on the album as well.

He was against this idea, considering it a disruption of the album's flow, but made the compromise by putting it in as a bonus track.

In his autobiography, Everett states that letting the song be used for Road Trip is one of the few real regrets he has ever had.