[9] Each Mr. Meeseeks is a tall, blue-skinned humanoid figure with elongated, narrow limbs, a large, bulbous head, beady black eyes, and a high-pitched voice.

Mr. Meeseeks usually exhibits a friendly, cheerful, and helpful demeanor; willing to assist the one who brought him into existence, however possible, in order to ensure their own death.

In "Meeseeks and Destroy", Jerry, Beth and Summer Smith are given a Meeseeks Box by Rick Sanchez to provide solutions to their problems: for Jerry, taking two strokes off his golf game, for Beth, making her feel better about herself, and for Summer, to make her popular at her high school.

Jerry uses a broken shelf and tomato in place of a golf club and ball to show that his game has improved, and the delighted Meeseeks cease to exist.

Meeseeks Boxes are featured as power-ups and loot boxes in the free-to-play role-playing video game Pocket Mortys, producing Meeseeks for the player to use in battles,[10] as well as in the virtual reality game Rick and Morty: Virtual Rick-ality, where a variant dubbed Mr. Youseeks can be summoned to aid in unreachable chores.

In 2006, Roiland created The Real Animated Adventures of Doc and Mharti, an animated short parodying the Back to the Future characters Doc Brown and Marty McFly, and the precursor to Rick and Morty, the second episode of which features the pair encountering the title character Scud of Scud: The Disposable Assassin, whom Harmon had written for from 1994–1998, serving to promote the series' 2008 revival.

[12] After the idea for Rick and Morty, in the form of Doc and Mharti was brought up to Adult Swim and a full television series entered development, Roiland had the idea for the episode "Meeseeks and Destroy" when, frustrated with the progress of a writing session, he suggested the introduction of a character who would blurt "I'm Mister Meeseeks, look at me!"

in a "most annoying" voice, which was then combined with Harmon's variation on Rob Schrab's Scud character,[13] each member of the species uttering the catchphrase upon being created or making a point.

I'm Cheddar & Sour Cream", with the product description reading "Mr. Meeseeks' tall, powder-blue figure is naturally emulated in this narrow can of Pringles crisps.

Looper described Mr. Meeseeks as "a symbol of the series", citing "his appeal [a]s the genie-in-a-bottle fantasy element" that the character provides as "a meditation on the nature of existence, setting the template for the show's ever-more frequent forays into philosophical contemplation.

"[29] GameSpot has stated that "there has been no character who has caused as lasting an impact [on the Rick and Morty franchise] as Mr. Meeseeks",[30] while Jake Lahut praised the character as "[r]esembling something between Gumby and the Smurfs, [as] a species who embod[ies] Aristotle’s key theory of teleology, the idea of design and purpose in each material thing.

[33] Den of Geek praised the character as a vindication of "[the] sort of outwardly happy folks [who] live a rich inner life of endless torment" and the concept of "@#%&*!