De Horne Vaizey was the daughter of Scottish insurance broker David Bell, and his wife, Elizabeth Morris Barton, and had six siblings, four brothers and two sisters.

[2] She met her second husband, George de Horne Vaizey, on a Mediterranean cruise, which she won in a short story competition.

"[5] De Horne Vaizey's daughter Gwyneth, nicknamed Kit, was the inspiration for the character Kitty in her 1902 work A Houseful of Girls.

The author mentions that Gwyneth really did share lessons with a family of five sisters, who "in many ways were like the book Rendells.

[7] Her obituary in the Sydney Morning Herald mentions that she had been "an invalid, crippled and confined to her bed for years".