Criticisms included long load times between levels and increased difficulty over the original 'Splosion Man.

[9] The aim of the game is to "splode" through a series of levels consisting of puzzles, traps, and enemies.

[10] Various new gameplay elements have been added to Ms. Splosion Man, including energy rails on which the protagonist can ride, and cannons that toss her in specific directions, some of which can be controlled by the player.

The game features both single-player and multiplayer cooperative campaigns, each including levels set in the outside world.

This causes a surge of energy to flow to a nearby experimentation platform where a yellow bow is falling.

As the bow touches the platform the surge of energy is released, and Ms. Splosion Man is created.

[16] For the first time in the series the character will escape the fictional Big Science facilities and venture out into the world.

We could have churned out new levels, but we wouldn't have had the time to add in new gameplay puzzles or cool new character stuff.

The lowest score came from Giant Bomb's Brad Shoemaker who gave the game 3/5 stars.

[34] Multiple critics gave the game a perfect score, including Richard Mitchell of Joystiq,[32] Ray Barnholt of 1UP.com,[25] and Terry Terrones of GamePro.

He stated in the review that the game was "another excellent, thrilling platformer from the insane team at Twisted Pixel".

Hatfield said "there is more creativity packed into one Ms. Splosion Man level than many other games can muster in their entirety".

[31] 1UP.com's Ray Barnholt awarded the title an A rating and praised the single and multiplayer modes.

[27] GameSpot's Carolyn Petit lauded the game's level design and cooperative mode.

[29] His criticisms included the amount of time it takes for Ms. Splosion Man to reach her full speed, and the lack of air control.