Ms. Tree is a comic book series named for its lead character, co-created by writer Max Allan Collins and artist Terry Beatty.

Throughout the series, in addition to isolated cases that often touch on social issues of the day, Ms. Tree's vendetta against the Muerta family is a major plot thread.

In contrast to genre conventions, she faces serious consequences throughout the series for these violent actions including arrest, imprisonment, commitment to a mental hospital, and involuntary medication.

In another genre divergence, the male Michael Tree's son, Mike Jr., inadvertently falls in love with the daughter of the Muerta matron.

The female Michael disapproves of this arrangement, but respects her stepson's decision while observing with amusement the Muerta matron's futile attempts to discourage it.

She decides to keep the baby, creating a unique series of adventures of this homicidal PI fighting off criminals even while dealing with a full term pregnancy, while the mob family she hates moves to protect her in their own way.