Published first by Aardvark One International and later by Mirage Studios, the story is set around the millennium and follows Gavia Immer, a governmental fauna agent (aka game warden), as he goes through an existential dilemma while watching videos his father left for him after his death.

The comic book's detailed artwork by Michael Zulli, which focused primarily on wildlife and nature, was superposed to a loose narrative with a druggy, dreamy, new age apocalyptic atmosphere.

His new job consists of displacing mutated animals ("animutes" or "biomutes") and collecting pH samples of the reservoir, which is frequently limed to compensate for the effects of acid rain.

Gavia is alone at this cabin (save for an occasional trespasser and the puma that stalks the mountains above the reservoir) but is in contact with his superiors through a video conferencing system, which he also uses to speak to his mother.

Most issues include sections called "Notes on the Environment" and "The Fraying Weave", which offered facts and often frightening statistics related to tropical rain forests, endangered animals, and other environmental concerns.

The Puma Blues creators Murphy and Zulli responded with an open letter titled "Not Fade Away", stating their intent to continue with or without Diamond's support.

[3] This incident was one of the primary factors leading to Sim's participation in developing the Creator's Bill of Rights[4] (which was signed by both Murphy and Zulli).

[5] The series received praise from Alan Moore ("quite impressive, quite ambitious"),[citation needed] Neil Gaiman ("intelligent and urgent mythology for the end of the millennium"),[citation needed] The Village Voice ("difficult but intriguing"), The Comics Journal ("Zulli's wildlife art is utterly breathtaking"), and Peter Laird ("a multi-level, imaginative, lushly-rendered story").