The origin of the name, Msambwe (plural Misambwe) refers to a hardy and wild fruits (sambwe) tree indigenous to the area.

[1] Fishing is the primary source of income, although coconut palm, buxa coloring,[4][A] cashew nuts and fruits are produced for trade.

The area's scenery is characterized by its beaches, rocky outcrops and low cliff tops and is relatively unspoiled.

[7][8] At one end of the beach is a "rocky headland of fossilized coral, which is a jumble of cracks, caves and chimneys that make an ideal roost for bats" and there are baobab trees in the vicinity.

As of 2001 the Msambweni Constituency had an area of 3,267 square kilometres (1,261 sq mi) with a population of 211,011 people.

A by-election which was held towards the end of December 2020 was marginally won by independent candidate Feisal Bader.

[4][20] The Kwake District Development Plan 2002–2008 attempted to improve fish landing sites and beach access for fisherman on the coast of Msambweni.

Silica sand is mined at Msambweni and transported to Nairobi to make bottle glass.

[23] Beekeeping and seaweed farming are also local occupation and its commercialization in the area has been supported by ACT!

[24] A result of its reef, the tourist industry is taking off in Msambweni attracting snorkelers.