Mseleni is a small settlement in Umhlabuyalingana Maputaland, northern KwaZulu-Natal, South Africa.

Mseleni Hospital is a 184-bed hospital which is split into 6 wards (labour, female surgical, paediatrics, male, female medical and isolation wards).

The local community development co-operative, Vuka Mabaso, provides a community hall, small business premises, market, library, and Internet café and computer training centre.

Based at the Children's Home, the AIDS orphan support programme Lulisandla Kumntwana (reach out to the child) is a church-based programme providing support to around 3000 orphans.

Mseleni is 3 km from Lake Sibhayi, a well known lake to everyone who grew up at Mseleni and to every young child living there, and it is 35 km from Sodwana Bay, a popular tourist destination.