Mtwalume, correctly known as Umthwalume, is a settlement in Ugu District Municipality in the KwaZulu-Natal province of South Africa.

The name "Mthwalume" is derived from isiZulu, and refers to the tall upright trees growing on the river bank.

The majority of the Mtwalume land area falls under the traditional chieftaincy of iNkosi Bhekizizwe Luthuli whose residency is near Turton.

Inland villages include eNyangwini, Nomakhanzane, Dingimbiza, eMabheleni, KwaQoloqolo, Othandweni, Nomoyi and Bangibizo.

There are a number of primary and secondary schools in Mtwalume, and they largely teach in isiZulu and English.