Mueang Mukdahan (Thai: เมืองมุกดาหาร, pronounced [mɯ̄aŋ múk.dāː.hǎːn]; Northeastern Thai: เมืองมุกดาหาร, pronounced [mɯ᷇aŋ mùk.dāː.hǎːn]) is the capital district (amphoe mueang) of Mukdahan province, northeastern Thailand.

Neighboring districts are (from the southeast clockwise) Don Tan, Nikhom Kham Soi, Nong Sung, Khamcha-i, and Dong Luang of Mukdahan Province; That Phanom of Nakhon Phanom province; and Wan Yai of Mukdahan Province.

To the east across the Mekong River is the Laotian province of Savannakhet.

The district dates back to the Mueang Mukdahan, which was administered by the Monthon Udon Thani.

[3] The district is divided into 13 sub-districts (tambons), which are further subdivided into 144 villages (mubans).