He was known for his nickname, "Moose", and for his signature mustache, and touchdown dance, which was featured in one of the opening cameos of Madden NFL 2006.

[3] He attended Waverly High School in Lansing, Michigan, where he earned three letters in football and an additional two in basketball and track.

He enjoyed a breakout season in 1995 under coach Nick Saban with 50 catches for 867 yards and 3 touchdowns while playing with quarterback Tony Banks and wide receiver Derrick Mason.

[11][12] Muhammad enjoyed an outstanding season in 1999 under new head coach George Seifert and his 96 receptions, eight touchdowns, and 1,253 receiving yards led to his first Pro Bowl selection.

Though the Panthers lost to the AFC Champion New England Patriots 29–32, Muhammad recorded the longest touchdown reception (85 yards) in Super Bowl history.

[4] Muhammad, who was due a $10 million roster bonus, and the Panthers could not agree on a contract after the 2004 season, and the team released him in February 2005.

Despite failing to catch several poorly thrown passes from rookie quarterback Kyle Orton, Muhammad held himself responsible and promised reporters he would improve his performance.

After Muhammad's criticism, coach Lovie Smith benched Orton in favor of a fully recovered Rex Grossman.

He had his first one hundred-yard day with the Bears in their season opener against the Green Bay Packers, and a second against the Minnesota Vikings during Week 3.

[30] Muhammad was the starting receiver for the Bears in Super Bowl XLI, making a touchdown reception in the first half of a 29–17 loss to the Indianapolis Colts.

[31] Muhammad became the third player in NFL history to score a Super Bowl touchdown with two different teams, joining Jerry Rice and Ricky Proehl.

While Drake stated he was unfazed by Muhammad's remark, he argued former Bears wide receivers Bernard Berrian, Justin Gage, and Bobby Wade developed in Chicago and enjoyed successful careers after leaving.

The couple have four daughters and two sons: (oldest to youngest) Jordan, Chase, Journey, Muhsin III, Maddon, and Kennedy.

Muhammad is also a spokesperson for the Men For Change organization which helps raise money for impoverished women's shelters.

[53] The Carolina Panthers presented Muhammad with their "Walter Payton Man of the Year" award in 1999 for his charity and volunteer work.