Muir College is a semi-private English medium high school for boys situated in the suburb of Vanes Estate in Kariega (Nelson Mandela Bay Metropolitan Municipality) in the Eastern Cape province of South Africa.

Muir College is one of the oldest boys english' speaking high school in South Africa, possibly tracing its origins back to 1822 when a Scottish educationalist, James Rose Innes MA (King's College, Aberdeen), established Uitenhage's first Free Government School in Cuyler Street on 12 October, with 60 pupils.

In 1904 a new, red-brick school building designed by celebrated architect William White-Cooper was opened on the Park Avenue site by Dr[doctor] Muir.

Although the division of the Cape Colony into East and West did not occur, a seal was prepared and is on view in the Cuyler Manor Museum.

"Nec Pluribus Impar", Latin for "Second to None" Stand and sing for auld lang syne, Shout till the rafters ring.

Let us sing to the Muir, To the school with the glorious memories, To the men of the past, and the name they have handed down to us; To the life and the strife, in the games that are stirring and calling us; Carry on!

Shane Gates, Michael Killian, Darron Nell and Marzuq Maarman are other notable Muirite rugby players.

Other famous Muirites include the Afrikaans poet A.D. Keet who passed his Intermediate exams at Muir where he also won the Nederlands school prize.