Due to its popularity, Televisa eventually expanded the topics of the stories the series depicted beyond those related to the earthquake.

In 1996, themes became darker in tone, including cases of rape, incest, child abuse, prostitution, LGBT discrimination and domestic violence.

It was hosted by actress and politician Silvia Pinal, who at the beginning of each episode would introduce the case the audience was about to view.

Instead of individual cases, various situations were presented in a continuous mini-series that ran throughout the weekdays (Monday – Friday) for one hour each day.

In the last half of the 1990s and until 2003, Televisa also offered another separate program, a spin-off of the Mujer, Casos de la Vida Real franchise.

A 2007 Televisa press release state that Mujer, Casos de la Vida Real would return on Saturday evenings starting in January 2008.

Having developed somewhat of a cult following due to its graphic material and handling of taboo subjects, a handful of people have taken up the task of recording and uploading recent reruns of the show to YouTube.

The material was slightly more professional than the low-budget settings offered by Mujer, and Callamos episodes revolved more around an actual plot rather than simply the case itself.