The mule drivers of Metsovo were one of the most significant professional transporters in the early modern Greece.
In 1707, written sources start mentioning them as already having a trade guild established which leads credence to the belief that they were occupied in the transportation of goods since even older times.
Throughout the 18th and 19th century they form one of the most active groups in the goods transportation industry in the Balkans.
Bοué describes the keratzides of Metsovo as the most famous in all "Albania" and among the most renowned in the Balkans.
According to Goudas, the transportation of goods from Bucharest, Constantinople (İstanbul), Belgrade and Adrianople (Edirne) was performed almost exclusively by Metsovites mule drivers.