The Muleshoe Heritage Center is commemorates the importance of ranching to West Texas.

The name Muleshoe can be traced in the region to Henry Black, when he registered a brand on November 12, 1860.

In 1877, Black purchased three houses on 40,000 acres (160 km2) in Stephens County, naming it Muleshoe Ranch.

Later, he built a large ranch house and a log schoolhouse, and established a small cemetery for family members.

[5] Muleshoe Ranch was supposedly named after the owner found a mule shoe in the soil.

In 1970, Muleshoe reached its pinnacle at over 5,000 residents, 200 businesses, two hospitals, two banks, a library, a newspaper, and a radio station.

During the early 1960s, Texas residents were eager to build a memorial to the mule for its strength and sparse eating habits, traits that endeared it to the pioneers.

In January 2024, a Russian hacktivist group hacked the town's water supply, causing flooding.

[9] [10] According to the United States Census Bureau, the city has a total area of 3.4 square miles (8.8 km2), all of it land.

This West Texas town experiences hot summer days and cool summer nights and cool to warm winter days and harsh, cold winter nights.

The park also features soccer and softball fields, a playground, fishing pond, and basketball courts.

Schools include: A branch of South Plains College provides classes for students aspiring to become licensed vocational nurses.