Its landscape is characterized by forested hills and agricultural plains.

In addition to the municipal seat of Domžale, the municipality also includes the following settlements: The remains of an ice-age hunter's dwelling found at Hag's Cave (Slovene: Babja jama) in Gorjuša date to 15,000 BP.

There is archaeological evidence of a pre-Roman Illyrian and Celtic settlement.

A local nobleman and owner of Krumperk Castle, Adam Ravbar, was a victor in the Battle of Sisak in 1593, in which the Ottoman army was defeated.

Economic development accelerated in the 19th century with the industrialization of the local craft of plaiting straw.