The main theme in her works is gender equality and the depiction of women's family life in India.

Ranganayakamma was born in Bommidi village near Tadepalligudem in West Godavari district of Andhra Pradesh on September 21, 1939.

Due to incompatibility, she left the first marriage after 12 years (1958–1970) and came to be known as "Ranganayakamma" ("Muppala" was the surname of her first husband).

The main theme in her works is gender equality and the depiction of women's family life in India.

Her novels were some of the first to use language closer to colloquial speech rather than the former Telugu literary standard (granthika bhasa).

[3] Her first novel, Krishnaveni, was published in the late 1950s and discusses gendered expectations in relationships through the portrayal of two strained marriages that are interconnected through the titular character's liaison with the other husband; there are two endings, an idealized, "happy" one for the expectations of Indian audiences and a more "realistic" gloomy one.

This book was a three-volume series and is now (since March 2005) available as a single volume with 746 pages in Royal size.

[8] She won the Andhra Pradesh Government Sahitya Akademi Award for Balipeetam in 1965, and it was made into a film in 1975.