He commissioned Saint Didacus of Alcalá Presenting Juan de Herrera's Son to Christ and frescoes from Carracci.

The mural decoration, with scenes from the saint's life, was done by the Bolognese painter Annibale Carracci.

In 1604 began designing the master of all the preparatory cartoons, but he became ill while personally directing the work 'in situ'.

So, the work was finished by his collaborators, who included Giovanni Lanfranco, Sisto Badalocchio and Francesco Albani.

The frescoes in the Herrera chapel were transferred to canvas at the request of the sculptor Antonio Solá, at the expense of Ferdinand VII (d. 1833), and arrived in Spain in 1851.