The film stars James Newill, Polly Ann Young, Dave O'Brien, Al St. John, William Royle and Chief Thundercloud.

[1][2][3] Joan Manning and George Weathers are partners in the trading post where miner Jim Smithers exchanges his gold dust for cash.

From the riverbank, Renfrew sees the gang escaping in canoes and apprehends one of the boats, where he discovers the money hidden among fur pelts.

Murder on the Yukon suffered stiff competition when Republic released Hi-Yo Silver, a feature-length motion picture based on the popular radio program, The Lone Ranger.

Among the highlights of watching Murder on the Yukon today are two famous comedians of the silent days, Snub Pollard and Al St. John, cast in minor roles.