The film stars Cary Grant, Claude Rains, Gertrude Michael, Kathleen Burke, Colin Tapley, Margaret Swope and Billy Bevan.

The local Turkish commander helps Andrews escape and confides that he is a British intelligence officer (initially "Smith," later named as John Stevenson) in disguise.

Realizing that a handful of men can't hold the fort, Andrews, Stevenson, and their troops set out over sand dunes and eventually enter the jungle with the tribesmen in hot pursuit.

The Last Outpost borrows stock footage from earlier productions, notably Merian C. Cooper's 1925 silent ethnographic documentary Grass—A Nation's Battle for Life.

Writing for The Spectator in 1935, Graham Greene gave a mixed review, describing the first half-hour of the film as "remarkably good" and the remaining 40 minutes as "quite abysmally bad".