The area of Murghob District is 37,300 km2, covering 26 percent of Tajikistan's soil, but only 0.17% of its population.

[3] Murghob District borders on Kyrgyzstan to the north, China to the east, and Afghanistan to the south.

[3] They are as follows:[6] It borders Afghanistan to the south, China's Xinjiang region to the east, and Kyrgyzstan to the north.

Within Tajikistan it is bordered to the west by four other GBAO districts and the Region of Republican Subordination.

The highest mountains are around the Fedchenko Glacier in the northwest and along the Pamir River in the south.