She graduated and returned to sell shoes in Saint-Étienne In 1981, she joined Roger Louret, whom she had met in Paris, in Monclar, with his theatre company, Les Baladins en Agenais.

In 1983, she returned to Paris with Annie Grégorio to work at the Petit Théâtre de Bouvard., where she also met Didier Bénureau.

Following that, she played in a role co-written with Didier Bénureau, Maman ou Donne-moi ton linge, je fais une machine, (Mother, or, Give me your laundry, I am washing a load), in 1986, in Avignon, and in 1987 in Paris, at the Théâtre de Dix heures.

They created her first one-woman-show together, Les majorettes se cachent pour mourir, in 1988, directed by Roger Louret.

[3] She has strongly criticized the French film industry for blacklisting[3] and refusing to cast LGBTQ actors, describing this behavior as "if you are gay, you are not desirable".

[3] Between 1992 and 2007, Muriel Robin was active in supporting concerts by the Enfoirés given for "the Restos du Cœur" created by Coluche and of which she became a sponsor until 2007.

The protesters included Marion Cotillard and Juliette Binoche, as well as Isabelle Adjani, Charlotte Gainsbourg, Jane Birkin and Muriel Robin.