The Shire of Murilla was a local government area located in the Darling Downs region of Queensland, Australia.

The shire, administered from the town of Miles, covered an area of 6,075.8 square kilometres (2,345.9 sq mi), and existed as a local government entity from 1879 until 2008, when it amalgamated with the Town of Dalby and the Shires of Chinchilla, Tara and Wambo and the southern part of Taroom to form the Western Downs Region.

Murilla Division was created on 11 November 1879 as one of 74 divisions around Queensland under the Divisional Boards Act 1879 with a population of 761.

On 15 March 2008, under the Local Government (Reform Implementation) Act 2007 passed by the Parliament of Queensland on 10 August 2007, the Shire of Murilla merged with the Town of Dalby and the Shires of Chinchilla, Tara and Wambo and Division 2 of Shire of Taroom (the Wandoan area) to form the Western Downs Region.

[4][5]The Shire of Murilla included the following settlements: Towns: Localities: