It is bounded to the north by the Bay of Biscay, to the east by the river Nalón, to the south by Pravia and the west by Cudillero.

Before the 19th century Muros de Nalón's history were tied to the municipalities of Pravia, Cudillero and Soto del Barco.

The 19th century brought major changes, and in the Peninsular War, French troops under the command of Marshal Michel Ney, sacked the town.

In September 1934, prior to the outbreak of Spanish civil war, the ship Vapor Turquesa landed a large cargo of weapons that were supposed to be sent to Ethiopia.

In Muros de Nalón, the Civil War broke a day later than other areas of Asturias.