Murphy is a census-designated place (CDP) in Jefferson County, Missouri, United States.

A post office called Murphy was established in 1894, and remained in operation until 1906.

[4] As of the census[3] of 2000, there were 9,048 people, 3,463 households, and 2,489 families residing in the CDP.

There were 3,613 housing units at an average density of 911.2 per square mile (351.8/km2).

22.1% of all households were made up of individuals, and 7.0% had someone living alone who was 65 years of age or older.