The Muscatine Pearl Finders formed the Northern Association along with the Clinton Teddies, Decatur Commodores, Elgin Kittens, Freeport Pretzels, Jacksonville Jacks, Joliet Jolly-ites and Kankakee Kays as fellow charter members, beginning league play on May 10, 1910.
On July 19, 1910, Muscatine was in second place with a 37–21 record under manager Lou "Roxey" Walters when the Northern Association permanently folded.
Muscatine finished with a 48–80 record, in the final regular season standings under managers Ed Coleman and Lou Walters.
Other 1911 Central Association members were the Burlington Cow Boys, Galesburg Pavers, Hannibal Cannibals, Keokuk Indians, Kewanee Boilermakers and Monmouth Browns.
[1][7][8] Baseball Hall of Fame inductee Sam Rice played for the 1912 Muscatine Wallopers, hitting .194 in 62 at bats.
Playing under returning manager Frank Boyle, the Buttonmakers finished 4.0 games behind the first place Waterloo Jays in the final eight–team standings.
With a 63–57 record under managers Ned Egan and Jesse Runser, the Muskies finished 18.0 games behind the first place Burlington Pathfinders in the final standings.
While the Muskies finished in third place with a 45–44 record under manager Ned Egan, but the franchise forfeited 34 of the wins after the season was concluded.
The ballpark is still in use today and known as Tom Bruner Field, named to honor a Muscatine High School teacher.