Muscatine High School is a four-year comprehensive public high school in Muscatine, Iowa.

Located approximately one mile east of U.S. Highway 61 in Muscatine, Muscatine High School teaches students from the city and adjacent rural areas.

The Muskies are members of the Mississippi Athletic Conference (MAC).

The school fields athletic teams in 21 sports, including:

This Iowa school-related article is a stub.