Long-lasting myalgia can be caused by metabolic myopathy, some nutritional deficiencies, ME/CFS, fibromyalgia, and amplified musculoskeletal pain syndrome.

Dehydration at times results in muscle pain as well, especially for people involved in extensive physical activities such as workout.

[10] Sudden cessation of high-dose corticosteroids, opioids, barbiturates, benzodiazepines, caffeine, or alcohol can induce myalgia.

[citation needed] When the cause of myalgia is unknown, it should be treated symptomatically.

Common treatments include heat, rest, paracetamol, NSAIDs, massage, cryotherapy and muscle relaxants.