The Museo d'Arte Contemporanea Donnaregina, often known as Museo Madre, or Donnaregina Contemporary Art Museum, is a museum of contemporary art in Naples, in Campania in southern Italy.

It is housed in the Palazzo Donnaregina, which was adapted for it by the Portuguese architect Álvaro Siza Vieira.

[3]: 88 Among the artists represented in the permanent collections are or were Sol LeWitt, Jeff Koons, Mimmo Paladino, Richard Long, Andy Warhol, Gilbert & George (Shitty World), Lucio Fontana,[2]: 44  Anish Kapoor, Jannis Kounellis, Giulio Paolini,[3]: 88  Francesco Clemente, Rebecca Horn, Mario Merz, Damien Hirst and Olafur Eliasson.

In 2009 the million-euro budget of the exhibition Barock led to a public dispute between Eduardo Cicelyn, at that time director of the museum, and Guido Cabib, an art dealer.

[5][6] In February 2011 the entire board of management of the Fondazione Donnaregina resigned.