The central atrium was moved to the front of the building and Doric columns still catch the eye of the viewer from the street 50 yards (46 m) away.

In the square in front of Villa Pignatelli there is the monument "Il pescatore" created in bronze by the sculptor Giovanni De Martino in 1920.

The architect Guglielmo Bechi designed the interior decorations of the apartments and the marble entrance staircase.

The property has changed hands since construction: upon the death of Acton in 1841, it was bought by Carl Mayer von Rothschild of the German family of financiers.

The villa maintains the gardens in front of the building, and houses a coach museum and a collection of French and English vehicles from the 18th and 19th centuries.