The construction of the Museo ng Muntinlupa commenced on April 25, 2017, with an allotted budget of ₱180 million by the city government.

It was opened to the public on March 1, 2019,[3] coinciding with Muntinlupa's 24th founding anniversary as a city.

[6] The building's façade design was based on the salakab, a traditional fishing trap made from weaved bamboo sticks and fasted by rattan rope often used by fishers working in Laguna de Bay, as a tribute to Muntinlupa's fishing industry, which is a major part of the city's economy.

[3] The ochre columns and wire netting were devised to manage the building's temperature by absorbing and deflecting heat.

[6] The museum hosts a main gallery, a mayor's hall, an interactive science centre,[3] and a theatre with 200 people seating capacity.