It previously was located in Pasig, Philippines at the ground floor of the Benpres Building, Exchange Road corner Meralco Avenue, Ortigas Center.

Under its first curator, Renato Constantino, the museum acquired the Juan Luna painting, España y Filipinas which complemented López growing collection of Filipiniana books and maps.

[6] The museum's collection will be split in two locations: at the Eugenio Lopez Center in Antipolo, Rizal and a space at The Proscenium at Rockwell.

[7][8] In May 2024, the museum announced that it would hold the first exhibition of its collections outside its premises at the University of the Philippines Visayas Main Building in Iloilo City from November 2024 until April 2026.

[9] The López Museum and Library is dedicated to housing artworks by reputed Filipino artists such as Juan Luna, and Felix Resurreccion Hidalgo, memorabilia relating to Filipino national hero Jose Rizal and Filipiniana materials and publications.