It is located near the forks of the Thames River.

The current building is designed by Raymond Moriyama, architect of Science North in Greater Sudbury, the Bata Shoe Museum in Toronto, and the National Museum of Saudi Arabia in Riyadh.

[2] The museum's collection contains 45,000 artifacts and 5,000 pieces of art.

[3] The museum's art collection includes works by Lawren Harris, one of the founders of the Group of Seven,[4] Kent Monkman, and Edward Burtynsky.

[5] In 2004, the London Health Sciences Centre gave the museum its medical artifact collection.